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KMID : 1098420210290050328
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Korean Journal of Medicinal Crop Science
2021 Volume.29 No. 5 p.328 ~ p.336
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Cognitive-enhancing Effects of Black Rice Aleurone Layer Extract on Scopolamine-induced Memory Impairment in Mice
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Choi Ji-Hye
Lee Eun-Byeol
Jang Hwan-Hee
Park Yong-Soon
Lee Sung-Hyen
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Abstract
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Background: The aim of this study was to investigate the potential of black rice (Oryza sativa L.) aleurone layer (BR) extract at improving the memory function of scopolamine-induced memory impaired mice.
Methods and Results: BR extract (150 and 300 ㎎/㎏), scopolamine (1 ㎎/㎏), and tacrine (10 ㎎/㎏) were administered to C57BL/6 mice. We analyzed the effects of BR extract on the scopolamine-induced cholinergic system, inflammatory response, and brain damage. It was observed that the BR extract offered protection against scopolamine-induced short- and long-term memory loss, and reduced learning deficits in the behavioral task. It also improved the cholinergic system and decreased the inflammatory cytokine levels. Furthermore, the BR extract downregulated the scopolamine-induced overexpression of amyloid β-peptide and caspase-3 in the hippocampus.
Conclusions: These results suggest that the BR extract may be beneficial as a dietary supplement, due to its neuroprotective effect against cognitive impairment and cholinergic deficit.
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KEYWORD
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Oryza sativa L., Aleurone Layer Extract, Cognitive-enhancing Effects, Memory Impairment
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